Supplement Information & Discounts

Research information on Supplement Therapy:
Dr. Boles Research Article on Supplement Treatment

Supplement Information (see Discount information below)

Dosage Guidelines

Dr. Boles currently uses the following dosage guidelines for cofactor (supplement) therapy in CVS, but strongly advises consulting with your own physician before beginning to take any of these supplements:

 

Coenzyme Q10 (CoQ10)

  • Promotes energy metabolism and an antioxidant.
  • Common dose in adults and children over age 10 years: 300 mg twice daily (600 mg a day).
  • Common dose in children under age 10 years: 10 mg/kg body weight twice daily.
  • Side effects: Rare, occasional insomnia from being over-energized can be dealt with by moving forwards in time the last dose of the day.
  • Caveats: Most brands have poor bioavailability. In Dr. Boles’ opinion, Trader Joes gel capsules are the best (Dr. Boles receives no money or goods from TJs).
  • Blood testing: Level should be higher than 4.0 mg/L (4,000 mcg/L), which is much higher than the normal level. Blood should be drawn after 4+ hours from last meal or dose, and at least a week after any change in dosing.

L-Carnitine

  • Promotes the metabolism of fats and detoxification of metabolic intermediates from affected mitochondria.
  • Common dose in adults and children over age 10 years: 500-1,000 mg twice daily (1,000-2,000 mg a day).
  • Common dose in children under age 10 years: 50-100 mg/kg body weight twice daily.
  • Side effects: Uncommon, occasional nausea or diarrhea (It is great for constipation); fishy odor. Side effects can be addressed by reducing the dose given.
  • Caveats: Can be bought over-the-counter or by prescription. Choose the least-expensive option.
  • Blood testing: Free level should be higher than 30-40 mcmol/L, which is the higher side of the normal level. Blood should be drawn after 4+ hours from last meal or dose, and at least a week after any change in dosing.

B Vitamins

  • There are several B vitamins that promote energy metabolism in different manners, including B1 (thiamine), B2 (riboflavin), B3 (niacinamide), B5 (pantothenate), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). A B100 tablet contains all of these B vitamins, plus others, at very high mitochondrial-targeting dosages.
  • Common dose in adults and children over age 10 years: One B100 tablet a day.
  • Common dose in children under age 10 years: One half of a B100 tablet a day.
  • Side effects: Nausea is common, so starting with one-half the dose for the first week is recommended. Some people can only tolerate one-half the dose.
  • Caveats: There are many brands to choose from.
  • Blood testing: Probably not helpful.

Vitamin C

  • Promotes energy metabolism and an antioxidant.
  • Common dose in adults and children over age 10 years: 500 mg twice daily (1,000 mg per day).
  • Common dose in children under age 10 years: 250 mg twice daily (500 mg per day), less under age 5 years.
  • Side effects: Very rare.
  • Caveats: There are many brands to choose from. Vitamin C acts primarily as an antioxidant, whose main purpose is to prevent future deterioration. Thus, success may look like no changes.
  • Blood testing: Probably not helpful.

Taken from http://molecularmitomd.com/?page_id=141

 

Supplement Discounts:

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