New Study II (Resting State Brain Response)

Resting State Brain Response to Chronic Nausea and Cuff Pain

The proposed study will examine the CNS circuitry of nausea in the human brain. Results found from motion sickness studies in healthy adults will be applied to guide the analysis of brain physiology in patients suffering from chronic nausea, i.e. cyclic vomiting syndrome (CVS).

Basic Criteria Eligibility: This study will aim to evaluate patients (n=25) diagnosed with CVS who are in an inter-ictal phase, i.e. at least 48 hours following cessation of any nausea/vomiting episode.

  1. Subjects age 18 to 80 years
  2. Diagnosis of Cyclic Vomiting Syndrome by Rome III criteria

EXCLUSION: Subjects who currently have an acute illness, those who are awaiting transplantation, and those who have a chronic illness, such as kidney failure, congestive heart failure, and diabetes. Use of prescription benzodiazepines within the previous 3 days, use of prescription opioids and self-reported use of cannabinoids within the previous 7 days are another exclusion criteria.
Another exclusion criterion is any nausea/vomiting episode within 48 hours prior to experimental session.

Principal Investigator:  Dr. Braden Kuo

Study Coordinator:  Shahar Castel, 617-726-0196