New Study II (Resting State Brain Response)

Resting State Brain Response to Chronic Nausea and Cuff Pain

The proposed study will examine the CNS circuitry of nausea in the human brain. Results found from motion sickness studies in healthy adults will be applied to guide the analysis of brain physiology in patients suffering from chronic nausea, i.e. cyclic vomiting syndrome (CVS).

Basic Criteria Eligibility: This study will aim to evaluate patients (n=25) diagnosed with CVS who are in an inter-ictal phase, i.e. at least 48 hours following cessation of any nausea/vomiting episode.

  1. Subjects age 18 to 80 years
  2. Diagnosis of Cyclic Vomiting Syndrome by Rome III criteria

EXCLUSION: Subjects who currently have an acute illness, those who are awaiting transplantation, and those who have a chronic illness, such as kidney failure, congestive heart failure, and diabetes. Use of prescription benzodiazepines within the previous 3 days, use of prescription opioids and self-reported use of cannabinoids within the previous 7 days are another exclusion criteria.
Another exclusion criterion is any nausea/vomiting episode within 48 hours prior to experimental session.

Principal Investigator:  Dr. Braden Kuo

Study Coordinator:  Shahar Castel, 617-726-0196

New Study I (Prospective Registry)

Prospective Registry in Cyclic Vomiting Syndrome at MGH

The researchers are looking for people to take part in the Cyclic Vomiting Syndrome Prospective Registry Study.  They are exploring the causes, progression, and impact of the disease.

Basic Criteria Eligibility:   Diagnosed with CVS and 18 years of age or older
Principal Investigator:   Dr. Braden Kuo
Study Coordinator:   Shahar Castel, 617-726-0196

International Vomiting Conference

Biology and Control of Nausea ad Vomiting 2013
(a Professional Conference)

October 3-4, 2013
University of Pittsburgh, Pittsburgh, PA


Nausea and vomiting are common highly aversive experiences for patients and result in reductions of appetite and quality of life. Progress in understanding the biology and treatment of nausea and vomiting has been slow partly because there is currently no focused scientific meeting to discuss and collaborate on these research topics. To address this void, Biology and Control of Nausea and Vomiting 2013 will be held at the University of Pittsburgh on October 3-4, 2013.

Biology and Control of Nausea and Vomiting 2013 is targeted to both basic researchers and clinical investigators working in the field of nausea and vomiting. Information provided will also be useful for clinicians needing an up-to-date presentation of treatments for nausea and vomiting, particularly difficult-to-treat cases.

For more information, visit the website: